|CytoJournal 2005, 2:13
Hodgkin lymphoma: flow me?
Michael W Beaty, Kim R Geisinger
Wake Forest University School of Medicine Department of Pathology Medical Center Boulevard Winston-Salem, North Carolina 27157-1072, USA
Combining fine needle aspirate cytology with flow cytometry immunophenotyping for the rapid diagnosis of lymphoproliferative lesions is commonplace practice in many institutions. Yet, a definitive diagnosis of Hodgkin lymphoma in many cases remains elusive, requiring subsequent tissue biopsy confirmation. In this issue of CytoJournal, Hernandez et al explore the potential role of using the increased CD4/CD8 T-cell ratio in lymph node fine needle aspiration specimens as a specific feature in diagnosing Hodgkin lymphoma. CD4/CD8 T-cell ratio comparisons are made with cytomorphologic diagnoses of reactive, atypical, non-Hodgkin lymphoma, and Hodgkin lymphoma cases.
Michael W Beaty
Wake Forest University School of Medicine Department of Pathology Medical Center Boulevard Winston-Salem, North Carolina 27157-1072
Source of Support: None, Conflict of Interest: None
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