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 CASE REPORT
CytoJournal 2005,  2:8

Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature


1 Department of Pathology, Division of Anatomic Pathology, the Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
2 Department of Pathology, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
3 Department of Cardiothoracic Surgery at the University of Alabama at Birmingham, Birmingham, Alabama, USA

Correspondence Address:
Darshana N Jhala
Department of Pathology, Division of Anatomic Pathology, the Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.1186/1742-6413-2-8

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We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.






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