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 RESEARCH ARTICLE
CytoJournal 2011,  8:7

Endoscopic ultrasound-guided fine-needle aspiration of metastases to the pancreas: A study of 25 cases


1 Department of Pathology, University of Pittsburgh Medical Center, S-417 BST, 200 Lothrop Street, Pittsburgh, PA 15261, USA
2 Department of Internal Medicine, Gastroenterology, University of Pittsburgh Medical Center Shadyside, 5230 Centre Ave. Pittsburgh, PA 15232, USA

Correspondence Address:
Walid E Khalbuss
Department of Pathology, University of Pittsburgh Medical Center, S-417 BST, 200 Lothrop Street, Pittsburgh, PA 15261
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1742-6413.79779

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Background: Metastases to the pancreas are an uncommon cause of pancreatic masses seen on endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). The purpose of this study is to retrospectively review the cytomorphology, clinical findings, and results of ancillary studies in a large series of these unusual cases. Materials and Methods: We searched our institution's pathology database for EUS-guided FNAs of the pancreas that were diagnostic of metastatic tumor over a 5-year period. The final cytologic diagnosis, results of ancillary studies, corresponding histological material, and clinical follow-up data were reviewed in these cases. Results: A total of 1172 pancreatic EUS-guided FNAs were identified, of which 25 cases (2.1%) had a confirmed diagnosis of a pancreatic metastasis. This included 12 (48%) cases of renal cell carcinoma, 3 (12%) melanomas, 3 (12%) small cell carcinomas, and 7 (28%) other malignancies. In these metastatic tumors involving the pancreas, 20 (80%) of the lesions were solitary. Four (16%) cases had no prior history of malignancy. The average time to diagnosis of pancreatic metastasis was 5.3 years. Immunohistochemistry and special stains were performed in 22 (88%) and 9 (36%) cases, respectively. Conclusions: Our data shows that although metastases to the pancreas are rare, they can present as a solitary mass many years after the primary malignancy is diagnosed and can even be the first manifestation of an extrapancreatic primary in a small number of cases. It is important to consider the possibility of a metastatic lesion in the pancreas because this may require a different management than a primary pancreatic tumor.






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