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Figure 3: Cytospin preparation of CSF of a case of melanoma displays large atypical cell with high nuclear cytoplasmic ratio present within hemorrhagic background; coarse black pigment is seen in the cytoplasm of an adjacent degenerated cell (a: May GrunwaldGiemsa, ×400). The pigment fails to stain for Prussian blue stain for iron (b). Increase cellularity of singly lying atypical cells is observed in majority of cases of unknown primary site of cancer (c: Pap, ×400)

Figure 3: Cytospin preparation of CSF of a case of melanoma displays large atypical cell with high nuclear cytoplasmic ratio present within hemorrhagic background; coarse black pigment is seen in the cytoplasm of an adjacent degenerated cell (a: May GrunwaldGiemsa, ×400). The pigment fails to stain for Prussian blue stain for iron (b). Increase cellularity of singly lying atypical cells is observed in majority of cases of unknown primary site of cancer (c: Pap, ×400)