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Figure 2: (a) A smear categorized as high grade squamous intraepithelial lesion. Isolated dysplastic cells with a high nuclear to cytoplasmic ratio. Nuclei are greatly enlarged, vary in size and shape, and contain hyperchromatic, coarsely granular clumped chromatin (Pap stain, ×400). (b) Histologic section of the case seen in Figure 2a showing a high-grade squamous intraepithelial lesion. There is lack of surface maturation. Nuclei throughout most of the thickness of the epithelium show pleomorphism, membrane irregularities and coarse chromatin pattern together with numerous mitotic figures, of which many are abnormal. (H and E, ×400)

Figure 2: (a) A smear categorized as high grade squamous intraepithelial lesion. Isolated dysplastic cells with a high nuclear to cytoplasmic ratio. Nuclei are greatly enlarged, vary in size and shape, and contain hyperchromatic, coarsely granular clumped chromatin (Pap stain, ×400). (b) Histologic section of the case seen in Figure 2a showing a high-grade squamous intraepithelial lesion. There is lack of surface maturation. Nuclei throughout most of the thickness of the epithelium show pleomorphism, membrane irregularities and coarse chromatin pattern together with numerous mitotic figures, of which many are abnormal. (H and E, ×400)