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Figure 4: (a) Thyroidectomy specimen demonstrated neoplastic cells in nodular goiter (H and E, ×400), (b) Thyroidectomy specimen demonstrated heterogeneous positive immunoreactivity to thyroglobulin (immunohistochemical for thyroglobulin, ×400), (c) Thyroidectomy specimen demonstrated nuclear stained pattern in tumor cells and follicular cells (immunohistochemical for thyroid transcription factor-1, ×400), (d) Lymph node containing metastatic carcinoma (H and E, ×400), (e) Lymph node demonstrated completely negative immunoreactivity to thyroglobulin (immunohistochemical for thyroglobulin, ×400), (f) Lymph node demonstrated nuclear stained pattern in tumor cells (immunohistochemical for thyroid transcription factor-1, ×400)

Figure 4: (a) Thyroidectomy specimen demonstrated neoplastic cells in nodular goiter (H and E, ×400), (b) Thyroidectomy specimen demonstrated heterogeneous positive immunoreactivity to thyroglobulin (immunohistochemical for thyroglobulin, ×400), (c) Thyroidectomy specimen demonstrated nuclear stained pattern in tumor cells and follicular cells (immunohistochemical for thyroid transcription factor-1, ×400), (d) Lymph node containing metastatic carcinoma (H and E, ×400), (e) Lymph node demonstrated completely negative immunoreactivity to thyroglobulin (immunohistochemical for thyroglobulin, ×400), (f) Lymph node demonstrated nuclear stained pattern in tumor cells (immunohistochemical for thyroid transcription factor-1, ×400)