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Figure 1: (a) Cellular smears with numerous epithelioid cells showing clear cytoplasmic vacuoles, and rich vascularity (Diff-Quik, ×200); (b) Rare focus with cellular atypia, nuclear pleomorphism and hyperchromasia (Diff-Quik, ×400). (c) Higher power of a lesional cell with a signet ring appearance (Diff-Quik, ×600); (d) Papanicolaou-stained smear showing a cohesive cluster of cells, two with a signet ring appearance (×400); (e) The cell block was paucicellular but did contain two small groups of lesional cells with interspersed macrophages (H and E, ×200); (f) Immunohistochemical staining for thyroid transcription factor-1 showing positive nuclear staining in the lesional cells (×200). CD68 and CD10 immunohistochemical stains were negative (not shown)

Figure 1: (a) Cellular smears with numerous epithelioid cells showing clear cytoplasmic vacuoles, and rich vascularity (Diff-Quik, ×200); (b) Rare focus with cellular atypia, nuclear pleomorphism and hyperchromasia (Diff-Quik, ×400). (c) Higher power of a lesional cell with a signet ring appearance (Diff-Quik, ×600); (d) Papanicolaou-stained smear showing a cohesive cluster of cells, two with a signet ring appearance (×400); (e) The cell block was paucicellular but did contain two small groups of lesional cells with interspersed macrophages (H and E, ×200); (f) Immunohistochemical staining for thyroid transcription factor-1 showing positive nuclear staining in the lesional cells (×200). CD68 and CD10 immunohistochemical stains were negative (not shown)